中华卫生杀虫药械

目的 研究2019—2022年山东省白纹伊蚊对常用卫生杀虫剂的抗药性水平及发展趋势，为科学防控白纹伊蚊及登革热疫情合理选择卫生杀虫剂提供科学依据。方法 采用WHO推荐的幼虫浸渍法和成蚊接触筒法进行白纹伊蚊抗药性监测。使用Excel 2010和SPSS 20.0软件，对2019—2022年山东省9个代表性监测点的白纹伊蚊的抗药性生测结果进行收集整理和统计分析，探讨不同监测点的抗药性水平。结果 对氯菊酯、溴氰菊酯和高效氯氰菊酯的生测结果显示，分别有3(3/5)个、4(4/6)个、4(4/5)个监测点的白纹伊蚊幼虫产生了中、高抗性；有6(6/7)个监测点幼虫对残杀威产生中、低抗性；有2(2/7)个监测点幼虫对双硫磷产生中抗，其他均为低抗。所有监测点白纹伊蚊成蚊对溴氰菊酯及高效氯氟氰菊酯均显示抗性，有5(5/6)个、7(7/8)个、3(3/4)个监测点成蚊对氯菊酯、高效氯氰菊酯、顺式氯氰菊酯产生了抗性；分别有1(1/7)个、1(1/8)个的监测点成蚊对马拉硫磷、残杀威产生了抗性。结论 山东省9个代表性监测点白纹伊蚊已产生不同程度的抗性，且对拟除虫菊酯类杀虫剂的抗性明显高于氨基甲酸酯类和有机磷类，各监测点应根据实际情况，调整杀虫剂的使用并持续加强抗药性监测工作，采取有效措施延缓抗药性的发展，科学防控白纹伊蚊。

Objective To investigate the resistance status and development of Aedes albopictus to commonly used insecticides in Shandong Province from 2019 to 2022, and to provide theoretical basis for the rational selection and use of insecticides, scientific prevention and control of Ae. albopictus and dengue fever. Methods Insecticide resistance was monitored by WHO recommended bioassays, including larvae-impregnation method and the WHO contact-tube method for adults. Excel 2010 and SPSS 20.0 was used to calculate and analyze the bioassay data of Ae. albopictus resistance to insecticides from 9 sample sites in Shandong Province from 2019 to 2022, and the resistance level was statistically analyzed. Results The results showed that Ae. albopictus larvae from 3(3/5),4(4/6), 4(4/5) sites showed medium or high resistance to permethrin, deltamethrin and cypermethrin, respectively. Ae. albopictus larvae from 6(6/7) sites showed medium or low resistance to propoxur. Ae. albopictus larvae from2(2/7) sites showed medium resistance to temephos, while the other sites showed low resistance. Ae. albopictus adults developed resistance to deltamethrin and cyhalothrin at all surveillance sites, and showed resistance to permethrin, cypermethrin and alpha-Cypermethrin at 5(5/6), 7(7/8), 3(3/4) of the surveillance sites, respectively. Ae. albopictus adults developed resistance to malathion and propoxur at 1(1/7) and 1(1/8) of the sites. Conclusion The larvae and adults of Ae. albopictus in Shandong have developed varying degrees of resistance to the commonly used insecticides, and the resistance to pyrethroids was significantly higher than that to urethane and organophosphorus. It is recommended that surveillance sites should adjust the insecticides use planning and strengthen insecticide resistance surveillance to delay the development of resistance and scientific prevention and control of Ae. albopictus.