中华卫生杀虫药械

目的 评估北京市某垃圾处理厂采集的家蝇种群对氯氟醚菊酯、敌敌畏、残杀威的抗性水平，为合理用药提供科学依据。方法 采用微量点滴法测定家蝇对氯氟醚菊酯、敌敌畏、残杀威3中杀虫剂的抗性，以及增效醚(PBO)、脱叶磷(DEF)的增效作用。结果 氯氟醚菊酯、敌敌畏和残杀威对所采集家蝇野外种群的LD₅₀分别为0.082、0.327、>100μg/只，家蝇对3种杀虫剂的抗性倍数分别为20.50、40.88、>190;增效剂PBO、DEF对氟氯氰菊酯增效比分别为13.67,3.04;PBO和DEF对敌敌畏的增效比分别为1.42、20.43。结论 北京市某垃圾处理厂家蝇对氯氟醚菊酯、敌敌畏、残杀威分别产生了不同程度的抗性，多功能氧化酶和羧酸酯酶调节的解毒代谢分别在家蝇野外种群对氯氟醚菊酯和敌敌畏的抗性中起着重要作用。

Objective To evaluate the resistance of Musca domestica population collected from waste treatment plant in Beijing to meperfluthrin, dichlorvos and propoxur, and to provide scientific basis for rational application of insecticides.Methods The resistance of M.domestica to meperfluthrin, dichlorvos and propoxur was determined by topical application, and the synergism of piperonyl butoxide(PBO) and S,S,S-tributyl phosphorotrithioate(DEF) was also tested.Results The LD₅₀s of meperfluthrin, dichlorvos and propoxur to the field population of M.domestica were 0.082,0.327 and >100 μg/fly, respectively.The resistance ratios were 20.50,40.88,>190,respectively.The synergistic ratios of PBO and DEF were 13.67 and 3.04 to meperfluthrin, and 1.42 and 20.43 to dichlorvos.Conclusion M.domestica from a waste treatment plant in Beijing developed different degrees of resistance to meperfluthrin, dichlorvos and propoxur.The detoxification metabolism regulated by multifunctional oxidase and carboxylesterase might play an important role in the resistance to meperfluthrin and dichlorvos, respectively.